대한구강악안면방사선학회

Korean Academy of Oral and Maxillofacial Radiology

학회지

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DMBA 매식과 방사선 조사로 유발된 백서 악하선 암에 존재하는 단백질에 관한 연구
저자 : 오성욱, 최순철, 박태원, 유동수
1997년|27권 2호|Page : 63-82|조회수 772
Full Text : 1997_63.pdf (1.4M)
TI : Tumor-associated proteins in rat submandibular gland induced by DMBA and irradiation

AU : Oh SO; Choi SC; Park TW; You DS
AD : Department of Oral and Maxillofacial Radiology, College of Dentistry, Seoul National University
SO : JKOMFR. 1997;27(2):63-82
ISSN : 1225-049X
PY : 1997
LA : KOREAN
CP : KOREA

AB : This study was performed in order to identify changes of the plasma membrane proteins in rat submandibular gland tumors induced by 7,12-dimethylbenz[a]anthracene [DMBA] and X-irradiation. Two kinds of tumor associated membrane proteins (protein A and B) were isolated with 3 M KCl extraction from rat submandibular gland tumors induced by DMBA and X-irradiation. To identify their antigenicities, immunoelectrophoresis and double immunodiffusion was carried out with various proteins extracted from liver, heart, skin and pancreas of adult rats and from embryonic liver, heart and skin. The rabbit antisera against the protein A did not cross-react with any of the proteins extracted from the above mentioned tissues, suggesting that protein A might be tumor specific antigen. However, the rabbit antisera against protein B was precipitated with proteins extracted from the liver of adult and embryonic rats. Polyacrylamide gel electrophoresis of these two proteins (A and B) showed that protein A was a dimer with molecular weights of 69,000 and 35,000 dalton, whereas protein B was a monomer with molecular weight of 50,000 dalton.

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